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Toxicology, Pharmacology and General & Specific Causation
Presented By: DRI and S-E-A
The program will provide an overview of the general principles of toxicology and pharmacology, and how toxicologists and pharmacologists examine general (what adverse effects are associated with a chemical or physical agent) and specific (did exposure to a chemical or physical agent cause an individual’s disease or ailment) causation. Throughout the webinar topics of current interest, such as opioids, ethanol, talc, glyphosate and cannabis, will be discussed to illustrate the principles of toxicology and pharmacology and the application of the Hill Criteria to the literature that exists for these substances.
What WIll You Learn?:
- General principles of toxicology and pharmacology
- Terms and definitions used by toxicologists and pharmacologist
- The causation paradigm used to evaluate allegations of adverse health effects due to chemical or physical agents
- The Hill Criteria and application of these criteria to literature available for substances of current interest
- Overview of literature for chemicals of current interest
Michael J. Wernke, R.Ph., Ph.D., S-E-A
Dr. Michael Wernke has over 30 years of experience in the areas of human health toxicology and pharmacology, risk assessment, risk communication, and hazard evaluation. He is also a licensed (Ohio) pharmacist. At S-E-A, Dr. Wernke is responsible for matters requiring the determination of the presence or absence of harmful or intoxicating chemicals, testing and analyzing data for harmful contaminants in food or the environment and evaluating contributing factors in the cause and manner of death or illness. He evaluates exposures to and human health effects of microbial organisms, ethanol, drugs, metals, chemicals, gases, and other occupational and environmental potential contaminants. Dr. Wernke also evaluates drug related cases including, but not limited to, intoxication, drug-related problems, hazardous drug combinations or overdoses, indications and contraindications, and drug labeling and warnings.
Matthew K. Brittain, Ph.D., S-E-A
Dr. Matthew K. Brittain is responsible for cases at S-E-A that require the determination of the presence or absence of harmful or intoxicating chemicals, testing and analyzing data for harmful contaminants in our food or environment and evaluating contributing factors in the cause and manner of death or illness. Evaluates exposures to and human health effects of microbial organisms, alcohol, drugs, metals, chemicals, pesticides, gases, and other occupational and environmental potential contaminants. Additionally, assesses laboratory procedures and testing methods to determine the integrity of relevant data and data collection methods for drug, pesticides, and other toxicological analysis. Also evaluate, drug related cases including, but not limited to, intoxication, drug-related problems, hazardous drug combinations or overdoses, indications and contraindications, and drug labeling and warnings. Immediately prior to joining S-E-A Dr. Brittain managed the Chemical and Pesticide Laboratories within the Consumer Protection Division of the Ohio Department Agriculture. The laboratory was the testing location for pesticide misuse case, residue testing, and formulation verification for the state of Ohio. He also consulted on public health and toxicological cases within the state of Ohio.
